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First published online July 11, 2008

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Mesodermal chemokine signals for endodermal migration

During vertebrate gastrulation, mesodermal and endodermal cells internalise through the blastopore and then migrate in different ways to establish the internal and external organisation of the embryo. Wnt/planar cell polarity signalling controls the mesodermal cell migration but what regulates the endodermal cell movements? Mizoguchi and colleagues now report that, during zebrafish gastrulation, the chemokine Sdf1, which is released by mesodermal cells, controls the dorsal migration of endodermal cells, which express the Sdf1 receptor Cxcr4 (see p. 2521). Morpholino knockdown of cxcr4a or sdf1a/sdf1b (sdf1) inhibits the directional migration of cxcr4a-expressing endodermal cells, whereas misexpressed Sdf1 attracts cxcr4a-expressing endodermal cells. Using a transgenic line that expresses GFP in the endodermal cells, they also show that Sdf1/Cxcr4 signalling regulates the formation and orientation of the characteristic filopodial processes that, the researchers suggest, may help the endodermal cells decide their direction of migration. These results provide important new insights into the control of endodermal migration during zebrafish gastrulation.

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Related articles in Development:

Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation

Takamasa Mizoguchi, Heather Verkade, Joan K. Heath, Atsushi Kuroiwa, and Yutaka Kikuchi
Development 2008 135: 2521-2529. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?