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Fig. 4. The primordium migrates in an uncoordinated manner in the absence of FGF
activity. (A) Images from a time-lapse movie of wild-type
migration, velocity 69 µm/hour. (B) Images from a time-lapse movie
of a cldnb:gfp fgf3-/-;fgf10-/- embryo taken
over 6 hours, showing the uncoordinated migration of the front and the back,
average velocity 11 µm/hour. (C) Graph showing the speed of
migration of tip (dark blue), the second rosette (blue) and the back (green)
of the wild-type primordium, and of the tip (red) and the back (yellow) of the
double mutant primordium, over a 10-hour period. (D) Kymograph of
wild-type migration; all cells move at a similar speed, as indicated by the
parallel lines of the kymograph. (E) Kymograph of a 3-hour movie of an
SU5402-treated mosaic wt primordium showing the uncoordinated migration of
cells within the primordium. (F) Kymograph of an 8-hour movie of a
SU5402-treated wt primordium showing the back and forth movement of the
primordium before it stops.
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