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Figure 8


Fig. 8. Model of the FGF-driven radial epithelialization leading to rosette assembly. Blue nuclei correspond to cells expressing Fgf ligands. The red nuclei correspond to cells expressing fgfr1 and pea3. In the leading region, cells have a mesenchymal-like characteristic. In the trailing region, Fgf-expressing cells retain mesenchymal fate (blue) and induce the epithelialization of their neighbors. These fully epithelial cells then `close the gap' that represents the different cell in the middle by coordinated apical constriction and, as a consequence, form a rosette. In absence of FGF activity, all cells are equally mesenchymal-like and no rosette can form.





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