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Figure 7


Fig. 7. Signalling via EcR is required for repression of Wg and cell cycle progression. (A,B) β-gal (red) for UAS-EcRdN flip-out clones in the wg-lacZ background. (C) BrdU (red) for UAS-EcRdN clones and (D) quantification of BrdU in 120 hour larval wings (see above); UAS-EcRdN clones (121.7±14.4) have significantly less BrdU than the control (246±19.7; P=0.0001). (E) PH3 (purple) for UAS-EcRdN clones and (F) quantification of PH3; UAS-EcRdN clones (13.0±4.0) have significantly less PH3 than the control (42.65±5.3; P=0.0001). (G) Model for Crol connecting steroid hormone signalling to cell cycle progression. Crol is upregulated in response to ecdysone signalling and increased Crol results in decreased wg mRNA expression. Reduced Wg signalling results in less Hfp, which leads to increased dm expression to drive S phase and mitosis via increased Stg.





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