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Fig. 7. The over-activation of chemoattraction led to similar results with
mathematical simulation and organotypic culture. (A-C) Simulation
of a local pulse of activator led to the formation of an accumulation of
cells, surrounded by a ring of inhibition. The size of this ring was
proportional to the activator concentration. (D-F) Patterns resulting
from the local application of BMP7-coated beads. The maximal area of
inhibition (red circle) was obtained with the maximal concentration of BMP7.
pu(x,0)=c*exp(-(x2+(y-0.5)2)*500)
with c=4, 8 or 24. Scale bars: 250 µm.
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