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Fig. 1. The Fat-Warts signaling network. A regulatory network perspective of
Fat-Warts signaling. Fat PCP signaling is indicated in green, Warts signaling
pathways in red. Drosophila gene names are used, except for CD44 and
Taz, which are only found in vertebrates. Regulatory inputs include Ds, a
ligand for Fat, and hyaluraonate (HA), a ligand for CD44, but other regulators
for Expanded and Merlin (?) remain to be identified. Pointed arrows indicate
positive effects, block arrows indicate inhibitory effects. As discussed in
the text, Warts is likely to have as yet unidentified substrates (?) involved
in cell division. Abbreviations: Atro, Atrophin; Ds, Dachsous; Dco, Discs
overgrown; Fj, four jointed; Mats, Mob-as-tumor suppressor; Taz,
transcriptional co-activator with PDZ-binding motif; Yki, Yorkie.
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