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Fig. 5. Fj and Ds expression gradients and the regulation of PCP. (A) dachsous (ds) expression, revealed by a ds-lacZ enhancer trap, is graded in the Drosophila eye, with higher levels at the poles (P) and lower levels at the equator (E). (B) four-jointed (fj) expression, revealed by a fj-lacZ enhancer trap, is in a complementary pattern, with levels high at the equator and low at the poles. (C-E) Schematic perspectives of polarity in the eye in different genotypes. Broken lines with arrows indicate vectors of planar cell polarity, which in the eye is manifest in the orientation of ommatidia. Magenta and blue lines represent the Ds and Fj expression gradients, respectively. (C) In wild-type flies, the arrangement of ommatidia is symmetrical with respect to the equator of the eye, represented here by arrows pointing out towards the poles. The vector of polarity can thus be thought of as ascending the Ds slope and descending the Fj slope. (D) In an fj^- mutant, the vector of polarity continues to ascend the Ds slope and PCP is essentially normal. (E) In an eye with fj mutant clones (left side) or fj overexpressing clones (right side), reversals of polarity occur where the change in fj expression causes a local reversal of the gradient (Zeidler et al., 1999).

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