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Fig. 2. Skeletal defects heal through recruitment of progenitor cells of their
own origin. (A) Pentachrome staining of the mandibular injury site
shows bone matrix deposition (blue-green) at post-surgical day 7. (B)
GFP-staining reveals that the majority of the cells in the injury site are
immunopositive, indicating their neural crest origin. (C) X-Gal
staining (a label for mesoderm) is detectable in the surrounding muscle, but
is absent in the defect. (D) After 7 days, the tibial defect exhibits a
similar amount of osteoid as the mandible. (E) The bony defect is void
of GFP-positive neural crest-derived cells. (F) Instead, the defect is
occupied by β-galactosidase-positive cells. cb, cortical bone (outlined);
is, injury site. Scale bar: 200 µm.
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