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Figure 6


Fig. 6. Pioneer axons influence pathfinding of follower axons. (A) Transplants resupply early RGCs to brn3c:GFP hosts injected with ath5 MO. (B-E) Dorsal views at 5 dpf, rostral upwards. Host axons terminate peripherally on the tectum; errors indicated by stars. (B'-E') Error quantitation. (B,B') In wild type>wild type;ath5 MO transplants, host follower axons pathfind normally. (C,C') When pioneers are replaced with ast cells, wild type follower axons make significantly more mistakes. (D,D') In ast>ast;ath5MO transplants, host follower axons make many errors. (E,E') When pioneers are replaced with wild-type cells, follower ast axons make fewer errors but are not completely rescued. Scale bar: 50 µm.





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