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Fig. 7. Proposed cellular mechanism for the control of small intestinal
fibroblast differentiation by Fgf9. Epithelially expressed Fgf9 interacts
with its receptors (Fgfr1 and Fgfr2) on mesenchymal stem cells. These cells in
turn express inhibitors of Tgfβ signaling that interact with mesenchymal
fibroblasts to inhibit their expression of
-SMA.
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