QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online August 12, 2008

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Bone regeneration: a tale of two progenitors

The skeleton is a self-renewing tissue, but what is the source of the stem cells that drive this renewal? Given the skeleton's dual embryonic origin - the cranium is derived from the neural crest (NC), the rest of the skeleton arises from mesoderm - are there one or two populations of skeletal stem cells? Now, on p. 2845, Jill Helms and colleagues report that two such populations exist in mice, and that their embryonic origin and Hox status influence their fate during adult bone regeneration. Using genetic cell labelling, they show that NC-derived skeletal stem cells heal injured mandibles and that mesoderm-derived stem cells heal tibial defects. In grafting experiments, although NC-derived stem cells heal both mandibular and tibial injuries, mesoderm-derived stem cells heal only tibial injuries, a limitation that is attributable to a mismatch between Hox expression in the host and donor cells. The researchers propose that this molecular difference gives skeletal stem cells a `positional memory' that may influence the outcome of bone grafts.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration

Philipp Leucht, Jae-Beom Kim, Raimy Amasha, Aaron W. James, Sabine Girod, and Jill A. Helms
Development 2008 135: 2845-2854. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?