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Fig. 5. Model of how slb cells with compromised Mil function can
restore the net migration of prechordal plate progenitor cells. Normally,
prechordal progenitors move persistently as a coherent cluster of cells. In
slb embryos, the cells undergo reduced net migration due to a
decrease in their cohesion and persistence. When injected with
mil-MO, the slb cells are capable of undergoing directed
migration as efficiently as WT cells, such that even under a circumstance in
which coherence of migration is reduced, if cell motility is increased, it
largely overrides the reduced directed migration. The length and size of
arrows reflect the speed and efficiency of the migration of cells with respect
to coherence and persistence.
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