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Fig. 6. Edg1 acts antagonistically against Mil in the directed migration of
prechordal plate progenitor cells. (A-F) In situ hybridisation of
dlx, hgg1 and ntl of WT embryos injected with 6.2 ng
edg1-MO alone (A,D) or co-injected with 4.3 ng mil-MO (B,E)
at tailbud stage, and of slb embryos injected with 6.2 ng
edg1-MO (C,F). (G-I) In situ hybridisation of dlx3
and hlx1 of WT embryos injected with edg1-MO alone (G) or
co-injected with mil-MO (H) at tailbud stage, and of slb
embryos injected with edg1-MO (I). (A-C,G-I) Dorso-animal views;
(D-F) lateral views. edg1-MO injection reduced anterior migration of
the anterior (A,D) and posterior (G) prechordal plate, compared with WT (see
Fig. 1A,E,I), and enhanced the
slb prechordal plate phenotype (C,F,I) (see
Fig. 1C,G,K). Co-injection of
edg1-MO and mil-MO cancelled out the effect of one another
and often gave rise to an embryo reminiscent to WT (B,E,H).
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