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Fig. 9. Model summarising how the Mil/S1P signal regulates the anterior
migration of prechordal plate progenitors. The Mil/S1P signal primarily
regulates the anterior migration of prechordal plate progenitors by modulating
cell motility and polarisation through PI3K, a key effecter of Pdgf
(Montero et al., 2003), and it
mediates directionality together with the Pdgf pathway through an unknown
mechanism. Furthermore, the Mil/S1P signal is seemingly able to modulate the
coherence of cell migration independently of Wnt11 function, which is required
for E-cadherin-dependent cell cohesion
(Montero et al., 2005).
However, it is still unknown whether Mil modulates cell cohesion/adhesion
through E-cadherin. There is interdependency between parameters, at least
between coherence and motility, as shown in
Fig. 5. Arrows indicate
regulation based on published and present results; dashed arrows indicate
possible co-operation between the signalling cascades.
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