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Figure 10


Fig. 10. hnRNP K suppression disrupts cytoskeletal cytoarchitecture. (A,C,E) Bilaterally injected control MO cultures exhibited normal distributions for all three cytoskeletal elements (A, phalloidin-stained F-actin; C, peripherin-immunostained neurofilaments; E, neuron-specific β-tubulin). (B,D,F) The cytoarchitectures of these elements was significantly disrupted in bilaterally injected hnRNP K MO cultures. F-actin circumscribed the cell body and was concentrated towards one side (B). Peripherin formed twisted filaments and aggregates (D), and neuronal β-tubulin formed ring-shaped structures (F).





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