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Fig. 7. Effects of hnRNP K knockdown on neurite outgrowth in culture.
(A,A') Neuron from control MO culture with neurite.
(B,B') Cells from bilaterally injected hnRNP K MO
cells lacking neurites. Arrowheads in A and B indicate cells identified as
neurons because they were positive for NF-M mRNA (by FISH).
(C) The fraction (±s.d., n=4 cultures) of NF-M
mRNA-positive cells that had neurites. In parentheses are the total number of
NF-M mRNA-positive cells scored. Asterisks indicate significant
variation relative to control MO and uninjected cultures (P<0.01,
one-way ANOVA). (D-E') Cells in control cultures immunostained
for NF-M. Whereas most cells that expressed NF-M had neurites (D), a few did
not (E). Scale bars in A and D apply to A-B' and D-E', respectively.
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