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Fig. 1. Location and properties of the `intervening zone' (IZ) progenitor
pool. (A) Scheme of the zebrafish anterior neural plate at the 3-
to 5-somite stage. Dorsal view, anterior up. The IZ area (identical to the
expression domain of her5 and her11) is outlined in red and
is composed of medial and lateral cell populations (MIZ and LIZ,
respectively). The IZ separates early neurog1-positive proneural
clusters: r2l, presumptive lateral neurons of rhombomere 2; r2MN, presumptive
motoneurons of rhombomere 2; vcc, ventro-caudal cluster. (B) Phenotype
observed at the 3- to 5-somite stage (orientation as in A) when two doses of
`Her5+Her11' are lost (e.g. upon injection of her5 or her11
antisense oligonucleotides): the MIZ is lost and replaced by a
neurog1-positive proneural cluster (arrows), whereas the LIZ is
intact. (C) Phenotype when four doses of `Her5+Her11' are lost (e.g.
upon injection of her5 and her11 antisense
oligonucleotides): neurog1 expression also becomes induced within the
LIZ (arrows). Adapted with permission from Ninkovic et al
(Ninkovic et al., 2005) and
Tallafuss and Bally-Cuif (Tallafuss and
Bally-Cuif, 2003).
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