spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 9


Fig. 9. Model for IZ formation in zebrafish. One side of the neural plate is represented (gray bar, the axial midline; red, MIZ and gli1 expression domain; black, LIZ). For simplicity, Gsk3β/PKA are shown together, although they might act in parallel. The E(Spl) and Gsk3β/PKA pathways inhibit neurogenesis throughout the IZ in a dose-dependent and cooperative manner. Gli1, expressed in the MIZ, acts antagonistically and promotes neurogenesis. Gli1 activity might be partially downregulated by Gsk3β/PKA. Responding to the sum of these activities, MIZ cells are more prone to commit towards neurogenesis than are LIZ cells. Gli1Act, activated Gli1; Gli1P, phosphorylated Gli1.





Right arrow Return to article