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Figure 7


Fig. 7. Role of Dlx3 during hair cycling. (A) Phospho-Smad1/5/8 and Lef1 expression in K14Cre;Dlx3Kin/f and K14Cre;Dlx3f/f at P18, P20 and P26. White arrowheads indicate specific expression. Scale bar: 50 µm. (B) Schematic diagram of Hf morphogenesis and onset of a new hair cycle. The area of Dlx3 expression is indicated in blue, dermal papilla in yellow and keratin-free germinal matrix compartment in gray. Dlx3 expression is first detected in the hair matrix; by anagen stage, Dlx3 is present in all differentiating hair compartments (matrix, cortex, cuticle and IRS) and later is detected in the telogen bulge. Our results demonstrate that Dlx3 is a target of Wnt, and that colocalization of phospho-Smad1/5/8 and Dlx3 is consistent with a regulatory role for BMP signaling of Dlx3. Our results determine that Dlx3 is a direct transcriptional regulator of Hoxc13, Gata3 and hair keratins, and that Dlx3 expression is necessary for the re-initiation of the hair cycle. HS, hair shaft; S, sebaceous gland; B, bulge; ORS, outer root sheath; IRS, inner root sheath; CU, cuticle; DP, dermal papilla.





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