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First published online August 25, 2008

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Proneural proteins keep mitotic time

Cell specification and division are precisely co-ordinated during neurogenesis but what controls the timing of mitotic entry? The answer for the neural precursors of the Drosophila external sensory organs, report Chang and colleagues, is the negative-feedback regulation of proneural proteins, a process that involves their degradation by the Phyl/Sina E3 ubiquitin ligase complex (see p. 3021). In Drosophila, the sensory organ precursors (SOPs) undergo asymmetric cell divisions after being specified by the proneural transcription factors Achaete (Ac) and Scute (Sc). The timing of the G2-M transition in SOP divisions controls daughter cell fate specification. In phyl mutants, the researchers report, Ac and Sc accumulation delays or blocks SOP division at the G2-M transition; ac and sc gene dose reduction rescues this defect. Other results indicate that the adaptor Phyl links the proneural proteins to the RING protein Sina. Because phyl is a transcriptional target of Ac and Sc, the researchers propose that, by initiating their own degradation, these proneural proteins control the timing of neural precursor division.

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Negative-feedback regulation of proneural proteins controls the timing of neural precursor division

Pao-Ju Chang, Yun-Ling Hsiao, An-Chi Tien, Yi-Chen Li, and Haiwei Pi
Development 2008 135: 3021-3030. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?