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Fig. 7. Wnt couples expansion to differentiation. (A) Axin2^lacZ expression (blue) is visible throughout the forelimb buds of E9.5 embryos (22 somites). (B) Sox9 expression (red) is absent in a nearby section through the same embryo as in A. Expression of Sox9 can be seen in other areas of the embryo, such as the neural tube. (C,D) At late E9.5 (27 somites), Axin2^lacZ is no longer active in the centre of the forelimb (C), where Sox9 is now expressed (D). (E,F) Sox9 immunostaining on longitudinal sections through the midregion of stage-matched wild-type (E) and Nmyc^-/- (F) E11.5 forelimbs. (G,H) Stage-matched E11.5 wild type (G) and Prx1::Nmyc embryo (H, n=5). (I,J) Sox9 immunostaining on longitudinal sections through the midregion of the forelimbs of the embryos shown in G,H. Dorsal is upwards and distal is rightwards (C-F,I,J). Nuclei are labeled in blue (B,D,E,F,I,J). Scale bars: 100 µm in A-F,I,J; 500 µm in G,H.

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