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Fig. 3. Heart laterality in embryos treated with Cai2+
antagonists. The indicated agents were implanted to the left or right of
Hensen's node at HH3++/4; heart laterality was scored 20 hours later. The
percentage of embryos with a right-looped (R, situs solitus) or left-looped
(L, situs inversus) heart is shown; the number of embryos per treatment is
indicated in parentheses. Treatments were: DMSO carrier solvent, Bapta-AM (30
mM), ionomycin (1 mM), U73122 (10 mM), EGTA (5 mM), ryanodine (2.5 mM),
ryanodine (2.5 mM) plus EGTA (5 mM), and calmidizolium (5 µM). Asterisks
indicate situs inversus frequencies that significantly differ from controls by
2 analysis (P<0.05).
