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Fig. 7. Effect of serotonin agonists and antagonists upon LR
Cai2+ levels. Fura-2-loaded HH6 embryos were treated
with serotoneric agents and imaged ventrally. The upper panel shows a
representative Fura-2 image; the lower panel is the line-scan quantitation of
fluorescent intensity versus left-right axis for that embryo, at the position
indicated by the yellow line in the upper panel. (A) Untreated embryo.
(B) The serotonin reuptake inhibitor fluoxetine reduced LR
Cai2+. (C) The 5-HT3 receptor agonist
2-methyl-5-HT reduced LR Cai2+. (D) The
5-HT3 receptor antagonist ondansetron elevated right-side
Cai2+. (E) The 5-HT4 receptor agonist
ML10302 reduced LR Cai2+. (F) The
5-HT4 receptor antagonist GR125487 elevated right-sided
Cai2+. Asterisk indicates Hensen's node; right (R) and
left (L) are as indicated in A.
