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Fig. 8. Heart laterality after treatment with serotonin agonists or
antagonists. The indicated agents were implanted to the left or right of
Hensen's node at HH4-HH6; heart laterality was scored 20 hours later. The
percentage of embryos with right-looped (R, situs solitus) or left-looped (L,
situs inversus) hearts is shown; the number of embryos per group is indicated
in parentheses. Treatments were: DMSO, serotonin reuptake inhibitor fluoxetine
(100 µM), 5-HT3 receptor agonist 2-CH3-5HT (5 mM),
5-HT3 receptor antagonist ondansetron (5 mM), 5-HT4
receptor agonist ML10302 (5 mM) and the 5-HT4 receptor antagonist
GR125487 (5 mM). Asterisk indicates situs inversus frequencies that
significantly differ from DMSO by 
2 analysis
(P<0.05).
