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Figure 3


Fig. 3. Matrix/striosome pattern of expression of ephrin A5 and EphA4. (A-C,G-I) Comparison between EphA4 and DARPP32 distribution on alternate sections of P2 (A-C) and P4 (G-I) mouse striatum. EphA4 expression (determined by in situ hybridization) was converted into false green (A,G) and DARPP32 immunostaining into false red (B,H). Overlays (C,I) reveal that the majority of the EphA4-negative patches appear positive for DARPP32 (arrowheads in C,I), indicating that the EphA4 receptor strictly belongs to the matrix compartment. (D-F,J-L) Comparison between EphA4 and ephrin A5 staining on alternate sections. EphA4 expression was converted into false green (D and J) and ephrin A5 expression into false red (E,K). Overlays (F,L) reveal a partially complementary pattern, with ephrin A5 being preferentially expressed in a subset of EphA4-negative patches, particularly in the centre of the striatum (arrowheads in F and L), but also in the EphA4+ compartment, and progressively downregulated between P2 and P4.





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