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Fig. 7. Schematic comparison of cell sorting processes occuring during hindbrain
segmentation and striatal compartmentalization. (A) In the
developing hindbrain, neural cells generated from adjacent rhombomeric
segments express repulsive ephrin ligands (in red) or Eph receptors (in green)
in a mutually exclusive pattern. This allows a strict restriction of cell
intermingling that results in the characteristic segmented pattern of the
rhombomeres. (B) In the developing striatum, striosome neurons (S) are
generated first (t1) and express high levels of ephrin ligands (in red) and
low levels of Eph receptors (in green). Matrix neurons are generated later
(t2) and express high levels of receptors and low levels of ligands. Matrix
and striosome cells first intermix and then partially segregate, through the
effects of bidirectional interactions, to form the mature mosaic pattern of
the striatum (t3). See text for further discussion.
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