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Figure 6


Fig. 6. IRS1 is present in SHH-mediated mouse medulloblastoma. (A) Hematoxylin and Eosin staining of a Neuro-D2-SmoA1 medulloblastoma depicts a desmoplastic medulloblastoma. (B) Adjacent normal cerebellar areas in the SmoA1 tumor model show very little IRS1 (red) immunostaining. (C,D) Increased IRS1 protein can be seen within the tumor at both 10x (C) and 63x (D) magnification (blue=DAPI). (E) Western blot analysis for both Ptch1+/- and SmoA1 medulloblastoma models show increased IRS1 expression coinciding with increased cyclin D2 expression. IGL, internal granule layer; ML, molecular layer.





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