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Figure 1


Fig. 1. Expression analysis of Cts7 and Cts8 on early post-implantation conceptuses. (A-C) In situ hybridization on E6.5 implantation sites. Cts7 and Cts8 expression (blue staining) is present in a subset of parietal trophoblast giant cells labelled by placental lactogen-I (Prl3d1). (D-F) Serial sections of E7.0 conceptuses. Cts7 and Cts8 are expressed by some parietal giant cells that are positive for Prl3d1, and in invasive giant cells at the margins of the ectoplacental cone (arrow). (G,H) E7.5 conceptuses. Cts7 and Cts8 staining is largely restricted to secondary invasive giant cells of the ectoplacental cone. The red arrowheads indicate that Cts7 expression in parietal giant cells extends slightly more distally compared with that of Cts8. (I) Every Cts8-positive giant cell (arrows) is in contact with a maternal blood vessel (asterisks). (J-L) Ectoplacental cone area of E8.5 conceptuses. Cts7 (J) and Cts8 (K) expression is restricted to a subset of trophoblast giant cells compared to the pan-giant cell marker proliferin (Prl2c2) (inset in L). Ctsl (L) is not expressed in this cell population. Scale bars: 200 µm in A-H,J-L; 100 µm in I.





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