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Figure 7


Fig. 7. Model of Cts7 and Cts8 function. Spiral artery remodelling is a concerted action between uterine natural killer (uNK) cells and trophoblast giant cells. Cts8 endows trophoblast giant cells with smooth muscle-degrading functions. This activity facilitates endovascular trophoblast invasion to complete the remodelling process. In addition, Cts7 and Cts8 may have complementary roles in promoting differentiation of the spiral artery-associated giant cell subtype from precursors within the ectoplacental cone.





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