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First published online September 5, 2008

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Wnt and FGF act jointly in limb growth

Growth, patterning and cellular differentiation are inextricably linked during development, but what coordinates these processes? To find out, ten Berge and colleagues have been studying how the skeletal core, connective tissues and muscles of the vertebrate limb develop from a proliferating mass of mesenchymal cells. On p. 3247, they report that Wnt and FGF signals coordinate growth with lineage specification during limb development. FGFs from the apical ectodermal ridge (AER) of the limb bud and Wnts from the AER and the surface ectoderm, they report, act synergistically to promote proliferation and maintain the limb mesenchymal cells in an undifferentiated state, but act separately to specify cell lineages. Thus, withdrawal of both signals causes cell-cycle withdrawal and chondrogenic differentiation, whereas Wnt exposure alone maintains proliferation and favours connective tissue differentiation. The authors incorporate these results into a new model for limb development in which localized Wnt and FGF signals coordinate growth, patterning and cellular differentiation, and guide the growing limb's spatial organization.

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Related articles in Development:

Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development

Derk ten Berge, Samantha A. Brugmann, Jill A. Helms, and Roel Nusse
Development 2008 135: 3247-3257. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?