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Fig. 3. Regulatory networks within the second heart field lineage. The model
presents an Isl1-dependent transcriptional network for the development of the
second heart field lineage. The LIM-homeodomain transcription factor Isl1
(blue) functions as an early regulator of a core network that determines right
ventricle and outflow tract development. The solid lines indicate that direct
in vivo activation of regulatory sequences has been demonstrated. Dotted lines
indicate genetic data or in vitro activation. Fgf8/10, fibroblast growth
factor 8 and 10; Foxa2, forkhead box a2; Foxc1/2, forkhead box c1/2; Foxh1,
forkhead box h1; Gata, GATA-binding proteins; Hand2, heart and neural crest
derivatives expressed transcript 2; Isl1, insulin gene enhancer protein;
Mef2c, myocyte enhancer factor 2C; Nkx2-5, NK2 transcription factor related,
locus 5; Smyd1, SET and MYND domain containing 1; Tbx1/20, T-box 1 and 20.
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