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Fig. 4. Isl1+ progenitor cells during cardiovascular development.
β-gal expression was analyzed in Isl1-nlacZ knock-in mouse
embryos at the indicated days of development and in the postnatal heart at day
3 (PN 3d) by X-Gal staining. Representative sections at each developmental
stage from E8.5-14.5 are shown (left), as are the corresponding heart
structures that express Isl1 (middle) and the lineage markers used to identify
the different cell types (right). Cranial (Cr)-caudal (Ca), right (R)-left
(L), and dorsal (D)-ventral (V) axes are indicated. A, atrial cavity; Ao,
aorta; AS, atrial septum; AVN, atrioventricular node; CG, cardiac ganglia;
Hcn4, hyperpolarization-activated cyclic nucleotide-gated K+ 4; LA,
left atrium; LV, left ventricle; MF20, antibody recognizing sarcomeric myosin;
OFT, outflow tract; PA, pulmonary artery; RA, right atrium; RV, right
ventricle; SAN, sinoatrial node; SM, smooth muscle; sm-actin, smooth muscle
actin; V, ventricle cavity. Parts of the figure are reproduced with permission
(Sun et al., 2007).
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