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Figure 3


Fig. 3. Germ cells initiate migration, but those ectopic to the gonads fail to die. (A-I) Lateral views of wild-type, p53 and outsiders mutant PGC development at stages 12-14. Anterior is left and dorsal up in all figures. PGCs are labeled with an anti-Vasa antibody. (A,D,G) PGCs in stage 12 embryos migrate into the mesoderm. (B) At stage 13, PGCs form a band of cells and are associated with one another in wild-type embryos. (E,H) In p53 and out embryos, some PGCs form clusters, but isolation of several PGCs becomes apparent. (C) At stage 14, wild-type PGCs reach the gonads. (F,I) In the mutants, PGCs successfully migrated to the gonads whereas errant PGCs are found ectopic to the gonads.





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