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Figure 2


Fig. 2. Heparan sulfate modification is required for lacrimal gland development. (A-C) Total heparan sulfate identified by the 3G10 antibody (red) was ubiquitously expressed in lacrimal gland (arrow) and the surrounding mesenchyme. HS, heparan sulfate. (D-F) Sulfated heparan sulfate recognized by the 10E4 antibody (red) exhibited restricted expression, with the strongest staining at the tip of Pax6-positive lacrimal gland bud (arrow). (G-I) Ndst1 is expressed in the lacrimal gland bud as marked by Pax6 staining (arrowhead). (J-L) Ndst1-/- animals failed to develop lacrimal gland as shown by aceto-carmine staining and GFP expression (arrow). p, posterior stalk; t, tip.





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