spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 4


Fig. 4. Lacrimal gland budding defects in Ndst1 mutants. (A,B) Lack of lacrimal gland bud in the Ndst1flox/flox;Le-Cre mutant at E14.5 (arrowhead). (C-F) The periocular expressions of Fgf10 (C,D, arrows) and Fgfr2b (E,F, arrows) were unchanged in mutant embryos when compared with wild type. (G,H) In the Ndst1 mutants, total heparan sulfate stained by the 3G10 antibody was also unchanged (arrow). (I,J) The Ndst1 mutant lost 10E4 staining for sulfated heparan sulfate in the fornix but not in the far side of conjunctival epithelium (I,J, arrows and arrowheads). The conjunctival epithelium is outlined. (K,L) Lack of lacrimal gland budding and BrdU+ proliferating cells in the Ndst1flox/flox;Le-Cre mutants. The lacrimal gland bud in the wild-type and the conjunctival epithelium in mutant embryo are marked by broken lines.





Right arrow Return to article