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Figure 6


Fig. 6. Fgfr2 signaling is required for lacrimal gland development. (A-D) Lacrimal gland development was abrogated in Fgfr2flox/flox;Le-Cre mutants. The control, but not Fgfr2 mutants, showed a mature lacrimal gland at birth (A,B) and a lacrimal bud at E14.5 (C,D, arrow). (E,F) The Fgfr2 mesenchymal knockout did not affect lacrimal gland budding, as shown by aceto-carmine staining (arrowhead). (G,H) Lack of lacrimal gland budding and cell proliferation (arrow) in the Fgfr2flox/flox;Le-Cre mutant conjunctival epithelium (outlined). (I,J) Fgfr2flox/flox;Le-Cre mutants lost heparan sulfate 10E4 staining in the fornix of the conjunctival epithelium (arrow), but not in the ectoderm further away from the eye (arrowhead). The conjunctival epithelia are outlined. (K,L) Phospho-Shp2 expression was present in the control lacrimal gland bud (K, arrow), but lost in the Fgfr2flox/flox;Le-Cre mutants (L, arrowhead).





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