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Fig. 3. The spatial pattern of tkv regulates the spatial pattern of Dpp
signaling and is sensitive to EGFR signaling levels. (A-C) Dpp
signaling is abolished in tkv- cells.
tkv- cells are marked by the absence of GFP (green) and
Dpp signaling is monitored by P-Mad staining (red). (D) Top: regulatory
mechanism proposed for the formation of the spatial pattern of tkv
expression: tkv is positively regulated by EGFR and negatively
regulated by a midline repressor, potentially Pointed (Pnt), also controlled
by EGFR. Bottom: schematic of the tkv patterns in the wild type, the
EGFR hypomorph (QY1, anterior striped gray), and the mutant with extra copies
of gurken (4PX, solid gray). The dashed line shows the boundary of
the wild-type pattern of tkv; cells inside the red box express
tkv in the wild-type background. In these cells, tkv
expression is lost in both the 4PX and QY1 mutants. (E,F)
tkv expression in the 4PX (E) and QY1 (F) backgrounds. The midline
gap is marked by a double arrowhead and the midline is marked by an arrowhead.
P-Mad (green) in 4PX (G) and QY1 (H) egg chambers, respectively.
The wild-type patterns of Dpp signaling and tkv expression are shown
in Fig. 1. Yellow dashed lines
mark the anterior boundary of the oocyte.
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