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Figure 6


Fig. 6. EGFR represses Br in the midline and is required for Br expression in the roof cells of Drosophila. (A-D) Experiments with genetic mosaics with GFP-marked clones of ras- cells reveal region-specific effects of EGFR signaling on Br expression. The dorsal midline is marked by an arrowhead in all images. (A) Merged image of Br expression (red) and GFP (green). (B) Midline ras- clones induce cell-autonomous ectopic expression of Br. (C,D) Lateral clones of ras- cells lead to cell-autonomous loss of Br expression in the roof cells. (E) A model proposed for the regulation of Br expression by EGFR: the spatial pattern of Br is established by the feedforward loop controlled by EGFR signaling. Br is induced in a wide dorsal domain. This effect is overridden in the dorsal midline cells, where Pointed, induced by high levels of EGFR signaling, represses Br.





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