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Fig. 6. A sequential recruitment and amplification model for Wnt-induced Lrp6
phosphorylation. (A) Initiation. Wnt-induced Fz-Lrp6 complex
formation promotes initial Lrp6 phosphorylation via Dvl recruitment of the
axin-Gsk3 complex. (B) Amplification. Initial Lrp6 phosphorylation
provides docking sites and thereby recruits additional Axin-Gsk3 complex to
promote further Lrp6 phosphorylation in cis and possibly in trans if/when Lrp6
multimerizes. See Discussion for details. For clarity, β-catenin, CK1 and
other proteins are omitted from the axin complex, the protein composition of
which may be different with and without Wnt stimulation.
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