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Fig. 4. The transcriptional changes in hematopoietic cells of
Tg(hsp:AML1-ETO) embryos correlate with the transcriptional changes
caused by AML1-ETO expression in human patients and in human cell
lines. The embryos used for array #1 were heat shocked two times at 40 and
42°C for one hour each time at 16 and 24 hpf respectively. The blood cells
were extracted at 38 hpf. The embryos for arrays #2 and #3 were heat-shocked
three times at 40, 42 and 42°C for one hour each time at 16, 24 and 38 hpf
respectively. The blood cells were extracted at 40 hpf. The ratios between the
signals from Tg(hsp:AML1-ETO) and wild-type samples are shown in the
heat map. The corresponding changes in the human studies are indicated in the
References column.
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