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Fig. 7. Loss of pronephric epithelial differentiation and vascular expansion in
osr1 morphants. Control (A,C,E,G) and osr1 morphants
(B,D,F,H) at 52 hpf. (A) Wild-type 52 hpf embryo showing position of
histological sections in C and E. (B) osr1 morphant embryo
showing position of histological sections in D and F. (C) Cross-section
at the level of the fin buds (inset) shows normal glomerular structure
(arrowhead) and connecting pronephric tubules. (D) Cross-section at the
level of the fin buds in an osr1 morphant (inset) shows absence of
pronephric tubules and glomerulus and expansion of cardinal vein (v).
(E) In more posterior sections of wild-type embryos, the pronephric
epithelial tubules (arrowhead) and cardinal vein are of roughly similar
dimensions. (F) In osr1 morphants, pronephric tubules are
reduced in diameter compared with wild-type (arrowhead) and the cardinal vein
(v) is significantly expanded. (G) Angiogram of wild-type
embryo trunk and tail region highlights the aorta (a) and the common
tail vein (v). (H) Angiogram of an osr1 morphant
highlights a grossly expanded venous plexus in the tail (v).
Intersomitic vessels were present in osr1 morphants but are not shown
in the confocal sections used in this projection.
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