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Figure 3


Fig. 3. Hox/Pbx- and Meis-binding sites are essential for element C activity. (A-D) Chick embryos were analyzed by X-gal staining after electroporation with reporter constructs driven by wild-type (A), HP1-site mutant (B), Meis-sites mutant (C) and HP2-site mutant (D) element C (schematized above). (E-I) Constructs driven by wild-type or mutant element C were used to generate mouse transgenic embryos that were analyzed by X-gal staining at around E8.5; the precise somite stage (ss) is indicated. (E) The total number of transgenic embryos obtained with each construct is summarized together with the numbers of embryos showing expression in the r3-r5 region, in r4 and r5 only, or in ectopic locations only. It should be noted that the level of reporter expression in r4/r5 is significantly reduced in the two positive embryos carrying the HP2 mutation. r, rhombomere.





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