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Figure 2


Fig. 2. Neurod1 and Math3 partially restore the optic nerve in Math5-null mice. (A) Dissected eyes from P30 mice. From left to right: Math5lacZ-KI/+, Math5Neurod1-KI/lacZ-KI and Math5lacZ-KI/lacZ-KI. (A1,A2) Cross-sections of the optic nerves from Math5lacZ-KI/+ and Math5Neurod1-KI/lacZ-KI dissected eyes shown in A were stained with Cresyl Fast Violet. (B) Histological sections of P30 eyes from wild-type and Math5Neurod1-KI/Math3-KI littermates. Arrowheads indicate the optic nerves. The double arrowhead indicates a rosette structure sometimes seen in Math5Neurod1-KI/Math3-KI retinas (inset). (B1,B2) Pou4f2 expression in wild-type and Math5Neurod1-KI/Math3-KI retinal sections. Representative lateral regions were used for comparison. ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer. Scale bars: 50 µm in A1; 200 µm in B.





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