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Figure 4


Fig. 4. Knockin Cdk2 expression is insufficient to rescue the Cdk2-/- meiotic defect. (A-D) Immunohistochemistry of Cdk1, Cdk2 and HA (Cdk2KI) on testes from 3-month-old mice. Sections stained for Cdk1: Cdk2+/+ (Aa), Cdk2+/+ Cdk1+/Cdk2KI (Ba), Cdk2-/- (Ca) and Cdk2-/- Cdk1+/Cdk2KI (Da). Sections stained for Cdk2: Cdk2+/+ (Ab), Cdk2+/+ Cdk1+/Cdk2KI (Bb), Cdk2-/- (Cb) and Cdk2-/- Cdk1+/Cdk2KI (Db). Sections stained for HA: Cdk2+/+ (Ac), Cdk2+/+ Cdk1+/Cdk2KI (Bc), Cdk2-/- (Cc) and Cdk2-/- Cdk1+/Cdk2KI (Dc). Arrows in Aa and Ba indicate leptotene and zygotene spermatocytes. Arrows in Ca and Da indicate cells with a pachytene-like morphology. Arrows in Ab indicate cells with zygotene morphology. Scale bar: 20 µm.





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