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Figure 1


Fig. 1. Otic commitment is progressive. (A) The prospective otic region (boxed) was isolated over a number of stages, and cultured in collagen. (B) Histogram showing the number of explants positive for Soho1 and hair-cell antogen (HCA). Greater than 50% of isolates explanted at 7-8ss showed autonomous Soho1 expression and HCA immunoreactivity. Asterisk represents the stage at which the autonomy of differentiation can be considered statistically significant. (C,D) Explants isolated at 5ss do not express Soho1 (C) and do not develop hair cells (D). (E,F) At 7ss, explants express Soho1 (E) and show good hair cell differentiation (arrow, F).





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