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First published online September 26, 2008

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Dishing up blood from ES cells

The primitive erythroid (PrE) lineage is the first mammalian blood cell lineage to form - in the embryonic yolk sac from its hemangioblast precursor - but little is known about the signals that specify it, or how it is regulated (primitive erythropoiesis occurs for just 48 hours). Gordon Keller and colleagues now employ an ES cell differentiation approach (see p. 3447) to investigate the involvement of Wnt and Notch signalling in PrE specification. By inducing genes and by assaying transcriptional activity and differentiation markers in ES cells, they have discovered that canonical Wnt signalling, together with Notch pathway inhibition by Numb, is required for an in vitro hemangioblast equivalent to differentiate specifically into the PrE lineage. By contrast, Notch signalling inhibits primitive erythropoiesis by upregulating Wnt pathway inhibitors. Of particular interest, the authors report, is the rapid downregulation of Wnt signalling, which suggests that just a short period of Wnt activity is required to establish the PrE fate, which might in turn underlie the transient nature of primitive erythropoiesis.

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Related articles in Development:

Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast

Xin Cheng, Tara L. Huber, Vincent C. Chen, Paul Gadue, and Gordon M. Keller
Development 2008 135: 3447-3458. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?