spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 2


Fig. 2. Chromatin control of cell proliferation and reprogramming. (A) PRC1 and PRC2 complexes help to maintain cells in an uncommitted, mitotically active stem-like state by silencing differentiation genes. Polycomb group (PcG) proteins are found in two main Polycomb repressive complexes (PRCs), the initiating complex PRC2 (red) and the maintenance complex PRC1 (green), but other PRC complexes have also been detected or predicted (purple, see B). PRC2 members Extra sexcombs (Esc)/EED (yellow oval) and E(z)/EZH2 (orange oval) methylate (blue hexagons) histone H3 at lysine 27 (arrow), and this epigenetic mark is recognized and bound by the chromodomain-containing protein Pc/HPC (green oval), a component of PRC1, to form stable, repressive chromatin. (B) Other forms of PRC (purple) have been detected and may instead repress cell proliferation and favor differentiation. The dynamic formation of distinct isoforms of PRC complexes may help to define the dynamic reprogramming of the genome at the transition from proliferation to differentiation. How PRC2 and PRC1 are recruited to specific genes remains poorly understood.





Right arrow Return to article