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Figure 6


Fig. 6. Repression of Shh signal transduction in C-RGCs causes intraretinal guidance defects. Confocal images of flat-mounted (A-C,H,I) and horizontal sections (D-G) from E16.5 mouse retinas electroporated with EGFP or EGFP-Ptc1{Delta}loop2. Immunolabelling for Pax2 is in red (F). In Ptc1{Delta}loop2-positive retinas, radial organisation is lost (C,F), fibres turn in aberrant directions including towards the periphery (arrows in C,F,G-I). Growth cones (yellow arrows, C) accumulate in the optic disc (od). The boxed regions in A and D indicate the locations of the high-magnification images shown in B and E, respectively. Scale bar: 200 µm in A,D,G; 75 µm in B,C,H,I; 100 µm in E,F.





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