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Figure 6


Fig. 6. Decreased expression of markers for ventral patterning during early Fz5-/- eye development. (A-F) The intact eye and surrounding tissue viewed from the cornea following whole-mount in situ hybridization. Dorsal is upward, as indicated in A. In the Fz5-/- mouse retina, ventral expression of Raldh3 at E10.5 and of Vax2 at E12.5 is decreased (arrowheads) whereas dorsal expression of Tbx5 (bracket) is minimally affected. (G,H) At E12.5, immunolocalization of Pax2 in the Fz5-/- retina extends beyond the immediate vicinity of the optic disc (arrowheads). (I,J) The pan-retinal distribution of Sox2 immunostaining is similar in WT and Fz5-/- retinas at E12.5; note the smaller size of the Fz5-/- eye.





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