spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. Increased apoptosis in the Fz5-/- retina at E10.5. (A,B) Whole-mount mouse embryos immunostained for cleaved caspase 3 showing increased apoptosis in the ventral Fz5-/- optic cup (arrowhead). The intact optic cup is seen from the cornea. Dorsal is upward, as indicated in A. (C-F) Horizontal sections from littermate embryos harvested 1 hour after injection with BrdU. Sections were stained with DAPI (C,D) or immunostained for BrdU and activated caspase 3 (E,F). The boxed regions in C,D show the locations of E,F. In the Fz5-/- optic cup, many more cells and cell fragments in both the inner (future retina) and outer (future retinal pigment epithelium) layers contain activated caspase 3. Proliferation appears to be grossly normal in the Fz5-/- optic cup.





Right arrow Return to article